Madoka Toyama

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OBJECTIVE To study the relation between fibrosis, pancreatic blood flow (PMBF), interstitial pH (pHi), and the effects of pancreaticojejunostomy (PJ) in chronic pancreatitis. BACKGROUND Chronic pancreatitis is associated with low PMBF and pHi, suggesting the existence of underlying ischemia. METHODS In cats, the main pancreatic duct was partially(More)
BACKGROUND The mechanism by which duct decompression (DD) relieves pain in patients with chronic pancreatitis (CP) is unknown. CP is associated with increased tissue pressure (IP), low pancreatic microvascular blood flow (PMBF), and interstitial pH (pH(I)). The aims of this study were to examine the effects of acute DD on PMBF, increased IP, and pH(I) in(More)
AIM The association between sarcopenia and nutritional status is thought to be an important problem in patients with cirrhosis. In this study, we investigated whether nutritional factors were related to sarcopenia in patients with liver cirrhosis. METHODS The subjects were 50 patients with cirrhosis aged 41 years or older. In this study, the subjects were(More)
Pledgets have been used in a variety of general and cardiovascular procedures for years. These small patches of felt, Tefon, or polytetrafluorethylene (PTFE) are used to reinforce suture lines or give added strength to weak tissues. We use felt pledgets with horizontal mattress sutures in the crural closure and creation of the fundoplication in laparoscopic(More)
OBJECTIVE To compare the short- and long-term morbidity and mortality rates of the standard Whipple pancreatoduodenectomy (SW) and its pylorus-preserving modification (PPW) in patients with malignant periampullary disease. DESIGN Retrospective medical record review and quality of life assessment by telephone interview. SETTING University medical center.(More)
This study evaluated the influence of hand dominance on skill acquisition during a basic laparoscopic skills curriculum. A total of 27 surgical residents (5 postgraduate year 3 [PGY-3] and 22 PGY-2 residents) participated in a 4-week laparoscopic skills curriculum. The residents were pre- and posttested on six laparoscopic tasks during weeks 1 and 4. During(More)
BACKGROUND Pancreatic blood flow is diminished in experimental models of acute and chronic pancreatitis. We attempted to develop a safe and reliable technique for its measurement in patients and to examine blood flow in patients with chronic pancreatitis and in control subjects. METHOD Pancreatic blood flow was measured using the hydrogen gas clearance(More)
OBJECTIVE The objective of this study was to investigate the effects of ethanol on pancreatic blood flow and interstitial pH in chronic pancreatitis. BACKGROUND Ethanol is known to contribute to the development of both acute and chronic pancreatitis. However, it is unclear how ethanol precipitates episodes of acute pancreatic inflammation in the setting(More)
BACKGROUND/AIMS Recent studies have suggested that, in the gastrointestinal tract, nitric oxide is an important mediator of alterations in blood flow and, in some organs, a second messenger involved in secretion. This study examined the role of NO in changes in pancreatic blood flow associated with basal and stimulated pancreatic exocrine secretion. (More)
BACKGROUND & AIMS Advanced chronic pancreatitis is associated with a reduction in pancreatic blood flow. To determine the physiological significance of this decrease, pancreatic interstitial pH was measured in a model of obstructive chronic pancreatitis in cats and in patients with chronic pancreatitis. METHODS In cats, pancreatic interstitial pH and(More)