Madhura Chakrabarti

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UNLABELLED Monoclonal antibody may undergo loss of immunoreactivity due to radiation damage when labeled with large amounts of 131I or 90Y for therapy. Our aim was to develop a method to protect an antibody during the labeling procedure. METHODS As a model we used T101, a murine monoclonal antibody directed against CD5 antigen. Iodine-125-T101 (100(More)
Protein catabolic states (i.e., sepsis and trauma) are thought to be associated with accelerated oxidation of branched-chain amino acids (BCAA). Branched-chain alpha-keto acid dehydrogenase (BCKAD), the rate-limiting enzyme for BCAA oxidation by muscle, is regulated by phosphorylation/dephosphorylation. Skeletal muscle BCKAD was only 2-4% active in control(More)
Thermodynamics of the thermal dissociation transitions of 10 bp PNA/DNA duplexes and their corresponding DNA/DNA duplexes in 10 mM sodium phosphate buffer (pH 7.0) were determined from differential scanning calorimetry (DSC) measurements. The PNA/DNA transition temperatures ranged from 329 to 343 K and the calorimetric transition enthalpies ranged from 209(More)
<lb>WORK-FAMILY BOUNDARY MANAGEMENT STRATEGIES: EXAMINING<lb>OUTCOMES, AND THE ROLE OF FIT<lb>by<lb>MADHURA CHAKRABARTI<lb>December 2011 Advisor: Dr. Boris B Baltes Major: Psychology (Industrial and Organizational) Degree: Doctor of Philosophy<lb>As more and more people attempt to effectively manage the simultaneous<lb>demands of work and family,(More)
Idoxuridine labeled with 125I was conjugated to polylysine. This conjugate was then coupled to the carbohydrate side chains of T101 monoclonal antibody (anti-CD5). The immunoreactivity, cell retention, cytotoxicity, and intracellular localization of this conjugate was tested in CCRF-CEM cells (CD5 positive). The conjugate had 68% immunoreactivity. The(More)
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