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India being a multilingual nation, with 22 recognised official languages, also has literature in all these languages; they find representation in the Digital Library of India (DLI) which holds over 120,000 books. DLI has driven the creation of a large number of applications to process and present the Indian language content. In this paper, we present the(More)
Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births; the incidence of CHD is up to tenfold higher in human fetuses. A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence risk. Here we report findings from a recessive forward genetic screen in(More)
Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity. We show that the human IFN-inducible oligoadenylate synthetases-like (OASL) protein has antiviral activity and mediates RIG-I(More)
Protein-protein interactions (PPIs) are the basis of biological functions. Knowledge of the interactions of a protein can help understand its molecular function and its association with different biological processes and pathways. Several publicly available databases provide comprehensive information about individual proteins, such as their sequence,(More)
Autosomal dominant leukodystrophy (ADLD) is an adult onset demyelinating disorder that is caused by duplications of the lamin B1 (LMNB1) gene. However, as only a few cases have been analyzed in detail, the mechanisms underlying LMNB1 duplications are unclear. We report the detailed molecular analysis of the largest collection of ADLD families studied, to(More)
Here, we studied systematically the association between amino acids, the constituents of protein sequences in datasets of different hierarchy, i.e. genome (human), protein type (membrane proteins), protein family (specific types of membrane receptors and transporters) and transmembrane helices versus loops (either for membrane proteins in general or(More)
— Telugu is an Indian language spoken by over 50 million people in the country. The language is rich in literature and has been studied by native and foreign linguists significantly, yet it has not benefited significantly from the recent advances in computational approaches for linguistic or statistical processing of natural language texts. However with the(More)
— Genes play a central role in all biological processes. DNA microarray technology has made it possible to study the expression behavior of thousands of genes in one go. Often, gene expression data is used to generate features for supervised and unsupervised learning tasks. At the same time, advances in the field of deep learning have made available a(More)
Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare and common genetic variants, but the functional effects of the risk variants remain to be understood. Protein interactome-based studies can facilitate the study of molecular mechanisms by which the risk genes relate to schizophrenia (SZ) genesis, but protein-protein(More)