Madhan Subramanian

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Women are exposed to estrogen in several forms, such as oral contraceptive pills and hormone replacement therapy. Although estrogen was believed to be cardioprotective, lately, its beneficial effects are being questioned. Recent studies indicate that oxidative stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of(More)
The incidence of ovulatory disorders is common in obese animal models. The mechanism behind this effect is unclear. We hypothesised that a high-fat (HF) diet induces alterations in neuroendocrine mechanisms resulting in anovulation in diet-induced obese (DIO) animals. Adult female DIO and diet-resistant (DR) rats were fed either chow or a HF diet (45%(More)
Changes in serum estradiol levels are associated with mood disorders in women. However, the underlying mechanisms are not clear. Because alterations in Brain-Derived Neurotrophic Factor (BDNF) and monoamine levels in the hippocampus and amygdala have been associated with anxiety disorders, we hypothesized that chronic treatment with a low dose of estradiol(More)
Chronic estradiol exposure induces oxidative stress in the hypothalamus to decrease 1 hypothalamic dopamine and cause hyperprolactinemia 2 Sheba M. J. MohanKumar , Badrinarayanan S. Kasturi , Andrew C. Shin , Priya 3 Balasubramanian, Ebony T. Gilbreath, Madhan Subramanian and Puliyur S. 4 MohanKumar 5 Neuroendocrine Research Laboratory, Departments of(More)
Despite the classically held belief of an "all-or-none" activation of the sympathetic nervous system, differential responses in sympathetic nerve activity (SNA) can occur acutely at varying magnitudes and in opposing directions. Sympathetic nerves also appear to contribute differentially to various disease states including hypertension and heart failure.(More)
Physical inactivity is an important risk factor in the development of cardiovascular disease. The rostral ventrolateral portion of the medulla (RVLM) is composed of heterogeneous populations of neurons that are involved in the regulation of the cardiovascular system. Because of functional heterogeneity, studying the changes in the gene expression of this(More)
<lb>THE EFFECT OF SEDENTARY CONDITIONS ON GABAERGIC TRANSMISSION IN<lb>THE RVLM<lb>by<lb>MARYETTA DONNA DOMBROWSKI<lb>December 2015<lb>Advisor: Patrick Mueller, Ph.D.<lb>Major: Physiology<lb>Degree: Doctor of Philosophy<lb>Physical inactivity is detrimental to our health and is a major risk factor for the<lb>development of CVD (138). Our laboratory has(More)
24 More people die as a result of physical inactivity than any other preventable risk 25 factor including smoking, high cholesterol, and obesity. Cardiovascular disease, the 26 number one cause of death in the United States, tops the list of inactivity-related 27 diseases. Nevertheless, the vast majority of Americans continue to make lifestyle 28 choices(More)
1 Women are exposed to estrogen in several forms such as oral contraceptive pills and 2 hormone replacement therapy. Although estrogen was believed to be cardioprotective, 3 lately, its beneficial effects are being questioned. Recent studies indicate that oxidative 4 stress in the rostral ventrolateral medulla (RVLM) may play a role in the development of 5(More)
BACKGROUND Chronic exposure to estradiol-17β (E2) in adult female rats increases mean arterial pressure by stimulating superoxide production in the rostral ventrolateral medulla (RVLM). However the mechanisms behind this phenomenon are unknown. We hypothesized that E2 exposure induces the gene expression of cytokines, chemokines and NADPH oxidase (Nox) in(More)