Madelyn Valle

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The molecular mechanisms by which extreme blood pressure elevation leads to vascular injury are not defined. To explore the hypothesis that activation of endothelium and platelets as manifested by increased concentrations of circulating endothelial microparticles and platelet microparticles could play a role in this target organ injury, we conducted a(More)
Three patients who had fat grafts implanted at operation for partial bone growth arrest had computed tomography scanning of the operated bone 3-10 years after operation so that the fate of the grafts could be clarified. Two patients had a bridge in the tibia and one in the femur. The density in Hounsfield Units in the enlarged cavities showed that the fat(More)
An improved method of inducing diabetes in dogs was developed. This method included 90% pancreatectomy, 2 mg/kg streptozotocin (STZ) perfused into pancreaticoduodenal artery, and the fixation suture of the duodenum to the costo-abdominal wall. Vasopressin injection administered to the animals before surgery reduced bleeding. All dogs used in this procedure(More)
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