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Alzheimer's disease (AD) is associated with pathological assembly states of amyloid-β protein (Aβ). Aβ-related synaptotoxicity can be blocked by anti-prion protein (PrP) antibodies, potentially allowing therapeutic targeting of this aspect of AD neuropathogenesis. Here, we show that intravascular administration of a high-affinity humanized anti-PrP antibody(More)
2602 Background: Dendritic cell (DC)-based vaccines are promising for cancer treatment. However, there are significant problems of efficient antigen loading and practicality of current approaches. Herpes simplex virus (HSV), unlike most viruses, infects DC very efficiently suggesting its use for antigen delivery to DC. The large size of HSV allows delivery(More)
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