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Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint Inhibitors
Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical impact in improving overall survival of several malignancies associated with poor outcomes; however, only 20–40% of patientsExpand
Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human
Receptor occupancy (RO) is a translational biomarker for assessing drug efficacy and safety. We aimed to apply a physiologically based pharmacokinetic (PBPK) modeling approach to predict the brainExpand
Model-based Dose Individualization of Sunitinib in Gastrointestinal Stromal Tumors
Purpose: Various biomarkers have been proposed for sunitinib therapy in gastrointestinal stromal tumor (GIST). However, the lack of “real-life” comparative studies hampers the selection of the mostExpand
Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors
Tyrosine-kinase inhibitors (TKIs) demonstrate high inter-individual variability with respect to safety and efficacy and would therefore benefit from dose or schedule adjustments. This studyExpand