Mackenzie R. Wehner

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Evidence-based therapies are available to reduce the risk for death from cardiovascular disease, yet many patients go untreated. Novel methods are needed to identify those at highest risk for cardiovascular death. In this study, the biomarkers β2-microglobulin, cystatin C, and C-reactive protein were measured at baseline in a cohort of participants who(More)
IMPORTANCE Indoor tanning is a known carcinogen, but the scope of exposure to this hazard is not known. OBJECTIVE To summarize the international prevalence of exposure to indoor tanning. DATA SOURCES Studies were identified through systematic searches of PubMed (1966 to present), Scopus (1823 to present), and Web of Science (1898 to present) databases,(More)
OBJECTIVE To synthesise the literature on indoor tanning and non-melanoma skin cancer. DESIGN Systematic review and meta-analysis. DATA SOURCES PubMed (1966 to present), Embase (1974 to present), and Web of Science (1898 to present). STUDY SELECTION All articles that reported an original effect statistic for indoor tanning and non-melanoma skin cancer(More)
BACKGROUND Frostbite injury occurs when exposure to cold results in frozen tissue. To screen drugs and other field therapies that might improve the outcome for a frostbite victim, it would be helpful to have a reliable and cost-effective preclinical in vivo model. OBJECTIVE We sought to create a novel mouse skin model of induced frostbite injury. This(More)
The conversion of light fields in photonic crystal fibers (PCFs) capitalizes on the dramatic enhancement of several optical nonlinearities. We present here spectrally smooth, highly broadband supercontinuum radiation in a short piece of high-nonlinearity soft-glass PCF. This supercontinuum spans several optical octaves, with a spectral range extending from(More)
IMPORTANCE Airline pilots and cabin crew are occupationally exposed to higher levels of cosmic and UV radiation than the general population, but their risk of developing melanoma is not yet established. OBJECTIVE To assess the risk of melanoma in pilots and airline crew. DATA SOURCES PubMed (1966 to October 30, 2013), Web of Science (1898 to January 27,(More)
Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme obesity [e.g. body mass index (BMI) ≥ 40 kg/m(2)], but their contribution to common obesity (BMI ≥ 30 kg/m(2)) and BMI variation in a multi-ethnic context is unclear. To fill this gap, we collected phenotypic and genetic data in up to 331 175 individuals from diverse ethnic(More)
IMPORTANCE Patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) (often termed nonmelanoma skin cancer or keratinocyte carcinoma [KC]) often develop new KCs, but information is limited on the frequency and timing of these subsequent tumors. This information is crucial to guide follow-up care. OBJECTIVE To determine the(More)
OBJECTIVES To draw attention to sex related disparities in academic medical leadership by investigating the representation of female leaders compared with leaders with moustaches. DESIGN Cross sectional analysis. SETTING Academic medical departments in the United States. PARTICIPANTS Clinical department leaders (n=1018) at the top 50 US medical(More)