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Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.

• Haitao Ji, Huiying Li, Mack L Flinspach, Thomas L Poulos, Richard B Silverman
• Journal of medicinal chemistry
• 2003

Selective inhibition of nitric oxide synthase (NOS) isoforms has great therapeutic potential in the treatment of certain disease states arising from the pathological overproduction of nitric oxide.… (More)

Double barrel shotgun scanning of the caveolin-1 scaffolding domain.

• Aron M. Levin, Katsuyuki Murase, Pilgrim J. Jackson, Mack L Flinspach, Thomas L Poulos, Gregory A. Weiss
• ACS chemical biology
• 2007

In the postgenomic era, a major challenge remains, elucidating the thermodynamic forces governing receptor-ligand specificity and promiscuity. We report a straightforward approach for mapping… (More)

Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase

• Mack L Flinspach, Huiying Li, +6 authors Thomas L Poulos
• Nature Structural &Molecular Biology
• 2004

Three nitric oxide synthase (NOS) isoforms, eNOS, nNOS and iNOS, generate nitric oxide (NO) crucial to the cardiovascular, nervous and host defense systems, respectively. Development of… (More)

The novel binding mode of N-alkyl-N'-hydroxyguanidine to neuronal nitric oxide synthase provides mechanistic insights into NO biosynthesis.

• Huiying Li, Hirotoshi Shimizu, +7 authors Thomas L Poulos
• Biochemistry
• 2002

A series of N-alkyl-N'-hydroxyguanidine compounds have recently been characterized as non-amino acid substrates for all three nitric oxide synthase (NOS) isoforms which mimic NO formation from… (More)

Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.

• Mack L Flinspach, Huiying Li, Joumana Jamal, Hui Huang, Richard B Silverman, Thomas L Poulos
• Biochemistry
• 2004

In a continuing effort to unravel the structural basis for isoform-selective inhibition of nitric oxide synthase (NOS) by various inhibitors, we have determined the crystal structures of the nNOS and… (More)

Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases.

• Huiying Li, Mack L Flinspach, +7 authors Thomas L Poulos
• Biochemistry
• 2005

A series of L-nitroarginine-based dipeptide inhibitors are highly selective for neuronal nitric oxide synthase (nNOS) over the endothelial isoform (eNOS). Crystal structures of these dipeptides bound… (More)

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