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Tropomyosin is present in virtually all eucaryotic cells, where it functions to modulate actin-myosin interaction and to stabilize actin filament structure. In striated muscle, tropomyosin regulates contractility by sterically blocking myosin-binding sites on actin in the relaxed state. On activation, tropomyosin moves away from these sites in two steps,(More)
The steric model of muscle regulation holds that at low Ca(2+) concentration, tropomyosin strands, running along thin filaments, are constrained by troponin in an inhibitory position that blocks myosin-binding sites on actin. Ca(2+) activation, releasing this constraint, allows tropomyosin movement, initiating actin-myosin interaction and contraction.(More)
Familial hypertrophic cardiomyopathy (FHC) is caused by missense or premature truncation mutations in proteins of the cardiac contractile apparatus. Mutant proteins are incorporated into the thin filament or thick filament and eventually produce cardiomyopathy. However, it has been unclear how the several, genetically identified defects in protein structure(More)
Interactions of the components of reconstituted thin filaments were investigated using a tropomyosin internal deletion mutant, D234, in which actin-binding pseudo-repeats 2, 3, and 4 are missing. D234 retains regions of tropomyosin that bind troponin and form end-to-end tropomyosin bonds, but has a length to span only four instead of seven actin monomers.(More)
A control numerical algorithm solving the timeoptimal problem for the reaction wheel pendulum system, fully effective in the open loop, is examined in the real-time system. There are two control tasks. The first is to transfer the pendulum from the lower to the upper equilibrium point. The second is to transfer the pendulum from the upper to the lower(More)
The paper is an attempt to interest the reader how to control real-time mechatronic systems under the MS Windows operating system. The authors refer to solutions that combine a software part and a hardware using the FPGA technology, together forming a comprehensive platform for the control purposes in the real-time. The main emphasis is placed on the(More)
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