Maciej Gutowski

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The effects of low level lead exposure on synaptic plasticity in hippocampal regions CA1 and CA3 were determined in adult rats in vitro. In the CA3 region the NMDA (N-methyl-D-aspartate)-independent mossy fiber-CA3 synapse potentiation was not influenced by chronic pre- and postnatal lead exposure, while in the same rats, in the CA1 region the(More)
The objective of the present study was, by using the Mongolian gerbil (Meriones unguiculatus) as an animal model, to provide data on the growth dynamics of central auditory and visual nuclei and to relate the growth of these structures to the growth of the entire brain. So far, no such systematic study has been performed in any mammalian species. The(More)
Finding the most stable tautomer or a set of low-energy tautomers of molecules is critical in many aspects of molecular modelling or virtual screening experiments. Enumeration of low-energy tautomers of neutral molecules in the gas-phase or typical solvents can be performed by applying available organic chemistry knowledge. This kind of enumeration is(More)
We describe a procedure of finding low-energy tautomers of a molecule. The procedure consists of (i) combinatorial generation of a library of tautomers, (ii) screening based on the results of geometry optimization of initial structures performed at the density functional level of theory, and (iii) final refinement of geometry for the top hits at the(More)
The possibility of electron binding to the HNNH 3 and H 2 NNH 2 tautomers of hydrazine was studied at the coupled cluster level of theory with single, double, and noniterative triple excitations. The HNNH 3 tautomer, with a dipole moment of 5.4 D, binds an electron by 1076 cm-1 whereas the H 2 NNH 2 tautomer forms neither a dipole-nor valence-bound anionic(More)
  • J Higgins, W E Ernst, C Callegari, J Reho, K K Lehmann, G Scoles +1 other
  • 1996
Using helium cluster-isolation spectroscopy we have prepared and characterized the lowest quartet state (1 4 A 0 2) of the sodium trimer. Upon excitation to the 2 4 E 0 electronic state, laser induced fluorescence excitation and emission spectra have been obtained. With the aid of ab initio calculations, the spectra have been vibronically assigned and new(More)
The relative stabilities of zwitterionic and canonical forms of neutral arginine and of its protonated derivative were studied by using ab initio electronic structure methods. Trial structures were first identified at the PM3 level of theory with use of a genetic algorithm to systematically vary geometrical parameters. Further geometry optimizations of(More)
Even a relatively small molecule with 10-20 atoms might have a few local minima, which correspond to different conformers. The number of local minima quickly increases with molecular size and the most common algorithms, driven by calculated forces, frequently identify a minimum, which is closest to the initial structure, rather than the most stable(More)
We examined the amount of long-term potentiation (LTP) in slices from the visual cortex and hippocampus of pre- and postnatally lead-exposed rats and controls at postnatal days (PND) 12-20. A dietary lead intake of 750 ppm by the dams resulted in a mean blood lead concentration in the suckling offspring of about 17' micrograms/dl. While high-frequency(More)
The object of this study was to compare the postnatal development of mossy fiber potentiation (MFP) and paired-pulse facilitation in the CA3 region of control and led-exposed rats. The postnatal development of MFP was not influenced by the chronic pre- and postnatal lead exposure nor did we find a statistically significant impairment of MFP in region CA3(More)