Maarten HP Kole

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Differential display of hippocampal tissue after entorhinal cortex lesion (ECL) revealed decreases in mRNA encoding the neuronal hyperpolarization-activated, cyclic nucleotide-gated channel HCN1. In situ hybridization confirmed that hippocampal transcripts of HCN1, but not HCN2/3/4, are down-regulated after ECL. Expression recovered at approximately 21 days(More)
Neurons target high densities of fast voltage-gated Na+ (Nav) and K+ (Kv) channels to their axonal initial segment (AISs) and nodes of Ranvier, subcellular domains governing the initiation and conduction of fast action potentials, respectively. Kv1 and Kv3 channels open rapidly to repolarize the action potential. In contrast, Kv7 channels, underlying the(More)
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