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During the clinical latency phase of human immunodeficiency virus (HIV) disease the central nervous system may be infected and begin to manifest subtle dysfunction. Our early investigations demonstrated persistent alterations in the sleep architecture of HIV-infected asymptomatic men. The major aims of this study were to delineate alterations of sleep… (More)
To provide a better understanding of the etiology of subjective sleep complaints in HIV-infected individuals, a study to evaluate sleep/wake disturbances in 10 healthy HIV-infected male volunteers was performed. All subjects were HIV-infected but had no history of AIDS-related infections, and considered clinically asymptomatic. Interviews and sleep… (More)
We retrospectively analyzed night-to-night variability in the indices of sleep apnea in a group of men who underwent consecutive polysomnograms (PSGs) in the evaluation of impotence. The study group consisted of 37 subjects. Fifty-seven percent of the subjects had an apnea/hypopnea index (AHI) of 5 or more on the first PSG, whereas 70% met this criterion on… (More)
Nasal continuous positive airway pressure (NCPAP) is considered the preferred medical treatment of obstructive sleep apnea. Because NCPAP exerts its beneficial effects by maintaining positive airway pressure, we proposed to test the ability of the newer "second generation" NCPAP machines to maintain a constant airway pressure during simulated breathing on a… (More)
We describe a patient with frontometaphyseal dysplasia (FMD), restrictive chest bellows disease, hypercapnic respiratory failure, and cor pulmonale. Treatment with intermittent supplemental oxygen, nocturnal nasal volume ventilation, and posture modification was successful in partial resolution of chronic hypoventilation and excessive daytime somnolence.
A 56-year-old woman presented with retrograde amnesia and confusion at the Emergency Department after falling down the stairs. Physical examination revealed a bilateral periorbital hematoma (raccoon eyes) and bilateral retroauricular ecchymosis, both strongly indicative of a basilar skull fracture.