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Between 1995 and 2001 echo-cardiography was performed in 244 children (128 boys, 116 girls) with acute lymphoblastic leukaemia (ALL) before the beginning of therapy with anthracyclines (medium 5.4 days after the diagnosis). The mean age at diagnosis was 5.4 years (range 9 months to 17.7 years). 189 children (97 boys and 92 girls) were included into the(More)
Nijmegen breakage syndrome (NBS) is a human autosomal recessive disease characterized by genomic instability and enhanced cancer predisposition, in particular to lymphoma and leukemia. Recently, significantly higher frequencies of heterozygous carriers of the Slavic founder NBS1 mutation, 657del5, were found in Russian children with sporadic lymphoid(More)
PURPOSE The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome. METHODS A single-center, retrospective analysis was performed of patients with documented TSC seen from 1988 to 2010 at the Children's Memorial Health Institute, Warsaw,(More)
Obesity is the main intermediate phenotype of primary hypertension (PH), and increased fat mass is directly related to target organ damage (TOD) and metabolic syndrome (MS). The aim of the study was to assess the sensitivity and specificity of body mass index (BMI), percentile-based, definitions of obesity [BMI > 95th percentile (pc)], and overweight (BMI >(More)
OBJECTIVES Investigating relationship between bone markers, cytokines and conventional prognostic parameters in patients with multiple myeloma (MM) and to assess the clinical application of bone turnover markers. DESIGN AND METHODS Sixty-four patients with MM were examined before treatment and followed for survival for over 7 years. Serum concentrations(More)
OBJECTIVE The aim of the present work is to investigate the segmental movement patterns of the spine during normal treadmill gait. DESIGN The spine movement during treadmill gait of ten healthy subjects (five men and five women) has been investigated using an optoelectronic measuring system. METHODS The spine was divided into seven segments, from C(7)(More)
Undiagnosed and untreated celiac disease (CD) constitutes an increasing skeletal health problem due to its association with low bone density and fractures. Examinations of skeletal status in children using dual-energy X-ray absorptiometry (DXA) are prone to size-related misinterpretation. In contrary, the analysis of muscle-bone relationship seems to limit(More)
The gait pattern in scoliotic patients differed from the gait pattern of the healthy subjects. The aim of the present paper was to describe the dependence of the gait pathology on the severity of the spinal deformity. Thirty five patients with confirmed scoliosis participated in the study. All patients underwent the clinical examination (X-ray and(More)
Central nervous system tumors diagnosed before the end of the first year of life differ from those found in older children and in adults. The differences include mode of clinical presentation, anatomical distribution, histopathological diagnoses, response to therapy, and outcome. The material consists of 56 children (23 girls and 33 boys), aged at(More)
BACKGROUND/AIMS We examined the persistence of HBV-DNA in sera collected 4-10 years after IFN-alpha therapy from patients with chronic hepatitis B who had seroconverted to anti-HBs antibodies. We also wanted to assess whether any association exists between HBV-DNA status and the IgG anti-HBs subclass responses. METHODS Sera were obtained from 38 patients(More)