• Publications
  • Influence
Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage.
Chromatin remodeling is tightly linked to all DNA-transacting activities. To study chromatin remodeling during DNA repair, we established quantitative fluorescence imaging methods to measure theExpand
  • 109
  • 14
  • PDF
The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.
The Mre11 complex (Mre11, Rad50, and Nbs1) is integral to both DNA repair and ataxia telangiectasia mutated (ATM)-dependent DNA damage signaling. All three Mre11 complex components are essential forExpand
  • 22
  • 4
  • PDF
Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair
Abstract The tumor suppressor BRCA2 is a large multifunctional protein mutated in 50–60% of familial breast cancers. BRCA2 interacts with many partners and includes multiple regions with potentiallyExpand
  • 24
  • 3
  • PDF
Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
Abstract BRCA2 is a key breast cancer associated protein that is predicted to have interspersed regions of intrinsic disorder. Intrinsic disorder coupled with large size likely allows BRCA2 to sampleExpand