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The global outbreak of novel A/H1N1 spread in human population worldwide has revealed an emergency need for producing a vaccine against this virus. Current influenza vaccines encounter problems with safety issues and weak response in high-risk population. It has been established that haemagglutinin(More)
Influenza virus A (H1N1) is an important subtype of influenza virus that makes numerous consequences throughout the world. In the first step of viral attachment, main antigenic site of the HA1 domain from the globular head of hemagglutinin (HA) binds to human cell receptors, starting the disease process. In order to produce recombinant subunit protein(More)
The critical obstacle in developing of an effective human influenza vaccine is continuous antigenic variation of influenza A viruses occurred each year. Conserved antigens are important candidates for vaccines because it is not necessary to match the designed strains with circulating strains. M2 as an ion channel protein induce protective immunity. On the(More)
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