MS FACS N. Joseph Espat MD

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Pancreatic cancer-gemcitabine (GEM) chemoresistance has been demonstrated to be associated with enhanced NF-kB activation and antiapoptotic protein synthesis. The well-known capacity of omega-3 fatty acids (n-3 FAs) to inhibit NF-kB activation and promote cellular apoptosis has the potential to restore or facilitate gemcitabine chemosensitivity. Four(More)
The dismal prognosis and progression to death for patients diagnosed with advanced stage (IV) pancreatic cancer has remained relatively constant for decades at approximately 6–8 months, with minimal incremental improvement in the overall survival noted with the advent of modern chemotherapy strategies. In considering potentially resectable pancreatic(More)
The potential value of hepatic intra-arterial chemotherapy (HIAC) can be considered from several different perspectives. A fundamental assumption for this discourse requires that, in this evaluation, HIAC is being provided with the intent of providing regional hepatic therapy for metastatic hepatic disease. With the exception of colorectal cancer (CRC),(More)
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