MR Posner

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BACKGROUND The purpose of the present investigation was to determine if the salivary counts of 40 common oral bacteria in subjects with an oral squamous cell carcinoma (OSCC) lesion would differ from those found in cancer-free (OSCC-free) controls. METHODS Unstimulated saliva samples were collected from 229 OSCC-free and 45 OSCC subjects and evaluated for(More)
Because regional spread to lymph nodes without systemic spread is a relatively common event in squamous cell cancer of the head and neck (SCCHN), it is possible that lymphoid-related receptors or cytokines might directly impact the growth of these tumors. In the present study, we have shown by flow cytometry and Western blotting that the central lymphoid(More)
BACKGROUND Locally advanced laryngeal and hypopharyngeal cancers (LHC) represent a group of cancers for which surgery, laryngectomy-free survival (LFS), overall survival (OS), and progression-free survival (PFS) are clinically meaningful end points. PATIENTS AND METHODS These outcomes were analyzed in the subgroup of assessable LHC patients enrolled in(More)
Editorial In this issue (1) David Montefiori and his colleagues have demonstrated both how far we have come since Margaret Heckler's 1984 prediction of an AIDS vaccine within 24 months, and how far we have to go before this promise is realized. This work extends to human vaccine trials' earlier observations related to the cooperativity in neutralization(More)
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