MM Guffy

Learn More
We investigated the effect of fatty acid alteration on the thermosensitivity of a mammalian tumor cell, the L1210 lym-phoblastic leukemia. Cells growing in Roswell Park Memorial Institute Medium 1640 with 5% fetal calf serum were modified with respect to their fatty acid composition by supplementing the media with either 40 (IM docosahexaenoic acid (22:6)(More)
We have investigated the effect of cellular fatty acid alteration on Adriamycin cytotoxicity using the L1210 lymphoblastic leukemia cell line. Cells growing in Roswell Park Memorial Institute Medium 1640 with 5% fetal bovine serum were modified with respect to fatty acid composition by supplementing their growth medium with 32 microM docosahexaenoic acid(More)
Toxic effects of excessive vitamin A and of excessive vitamin ADE were studied in 9 mixed Labrador Retriever pups. Clinical signs were loss of body weight, dullness, emaciation, roughened coat, evident pain in limb joints, and retarded growth. Radiologic changes were decreases in overall length and thickness of long bones, development of osteophytes,(More)
Nineteen German Shepherd Dog-Greyhound crossbreeds in 7 litters were evaluated by pathoanatomic and/or radiographic examination of their pelves when 12 to 24 months old (mean, 19 months). The prevalence of hip dysplasia in the crossbreeds was 42% (8/19). The prevalence of hip dysplasia in purebred German Shepherd Dog half-siblings in 16 litters produced by(More)
OBJECTIVE To investigate the relationship between pelvic muscle mass and development and expression of canine hip dysplasia (CHD). DESIGN Prospective study. ANIMALS 5 Greyhounds with anatomically normal hip joints, 59 German Shepherd Dogs (23 with CHD, 24 with near-normal hip joints, and 12 with normal hip joints), and 18 German Shepherd Dog-Greyhound(More)
We examined the effect of rate of temperature rise on the thermosensitivity of a murine lymphoblastic leukemia. L1210 cells suspended in RPMI 1630 medium:5% fetal bovine serum at pH 7.4 were heated from 37 degrees C-42 degrees C, or 44 degrees C over variable times (immediately, 30, 60, 120, 180 min) in a circulating water bath controlled by an electronic(More)