MJ Chiuchiolo

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Background The HIV-neutralizing activity of monoclonal antibodies 2F5, 4E10, and Z13 have shown that the membrane-proximal external region (MPER) of HIV Env is an important vaccine target, but development of an immunogen that elicits similar virus-neutralizing antibody responses against the MPER from a wide range of subtypes has been difficult to achieve.(More)
Methods We are using vesicular stomatitis virus (VSV) as a vector platform for delivery of Env immunogens as transmembrane glycoproteins. We have investigated a variety of vector designs and Env modifications to identify combinations that balance the practical requirement for vector genetic stability with factors influencing antibody responses including(More)
Background Immunity elicited by live attenuated vaccines confers protection against viral pathogens causing measles, yellow fever, smallpox and others, but this approach is not well suited to HIV vaccine development. Accordingly, to develop a vaccine that incorporates features of a live virus that make it immunogenic without the inherent safety issues(More)
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