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TGF-β potently induces apoptosis in Burkitt's Lymphoma (BL) cell lines and in explanted primary human B lymphocytes. The physiological relevance and mechanism of TGF-β-mediated apoptosis induction in these cells remains to be determined. Here we demonstrate the requirement for TGF-β-mediated regulation of BIK and BCL-X L to activate an intrinsic apoptotic(More)
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