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Data of 52 patients, 29 women and 23 men aged 32-68 years (mean age 47 years) with essential hypertension, participating in three open therapeutic trials with either enalapril, lisinopril, or perindopril were evaluated to assess the effects of angiotensin-converting enzyme (ACE) inhibition on glucose and lipid metabolism. The 75-g oral glucose tolerance(More)
AIM Our clinical experience with high - frequency SCS for FBSS in patients with predominant low back pain is presented. MATERIAL AND METHODS After a trial period, 100 % (21 out of 21) of patients with FBSS with predominant low back pain reported a significant improvement in visual analog scale (VAS) pain score and underwent permanent implantation of the(More)
The pharmacokinetics of acetylsalicylic acid (ASA) and its metabolites salicylic acid (SA) and salicyluric acid (SUA) were studied in 12 healthy young volunteers after oral administration of low (30 and 100 mg) and moderate (400 mg) doses. Plasma and urine were assayed for the above drugs by high-performance liquid chromatographic method. Individual(More)
OBJECTIVES This study compared long-term results of the treatment of idiopathic clubfoot at two different University orthopaedic departments. BACKGROUND The treatment of clubfoot is still controversial due to different severity and different treatment philosophies. METHODS Authors retrospectively analyzed a group of 273 feet (145 patients) operated on(More)
A two-compartment disposition model of ascorbic acid (AA) pharmacokinetics with saturable and time-constrained intestinal absorption was developed. The model was fitted to pharmacokinetic data obtained after oral administration to nine healthy volunteers of two effervescent dosage forms differing in AA content: Celaskon 60 mg (CK60) and Celaskon 500 mg(More)
54 healthy volunteers or patients with normal kidney and liver function, 17 patients with decreased kidney function and 12 dialysed patients were evaluated for their serum hippurate accumulation and kidney excretion. It was found that there was an inverse relationship between serum hippurate and the clearance of endogenous creatinine (CCr) and a free(More)
Middle molecule (MM) fractions were isolated from the erythrocytes of patients in chronic renal failure on conservative treatment, and healthy subjects and fractionated on Sephadex G 15. Most MM fractions were found in markedly higher concentrations in erythrocytes than in plasma. A model inhibitor of gluconeogenesis found previously in plasma and urine of(More)
BACKGROUND The achievement of low density lipoprotein cholesterol (LDL-C) target levels, as recommended by the evidence-based international guidelines, represents the crucial prerequisite for maximal cardiovascular risk reduction in patients with dyslipidemia. OBJECTIVES The efficacy of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins)(More)
Nitric oxide (NO) belongs to signal molecules and modulates notably rapid and dynamic processes. Interests are focused on the decreased NO synthesis by endothelial and mitochondrial nitric oxide synthases with the metabolic (i.e. insulin resistance, diabetes, energetical dysbalance) and vascular (i.e. hypertension, atheroslerosis) consequences. A(More)