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During the last 10-15 years the number of nonsteroidal antiinflammatory drugs (NSAID) has increased significantly [5]. In addition to the previously known derivatives of salicylic acid and pyrazole, the derivatives of anthranilic, phenylpropionic, and indoleacetic acids and of other chemical groups are used in medical practice. As a rule, NSAID show marked(More)
Active immunization of white rats against the catecholamine analogue, sydnophen, results in physiological changes extending over two months. The levels of noradrenaline in blood, and dopamine in brain, were depressed, some behavioural activities were reduced and alcohol consumption was lowered. On this basis, active immunization against various(More)
It is known that amino derivatives of pyridine have a broad spectrum of biological activities [7, ii]. Among derivatives of 2,4-diaminopyridine we find compounds with antihypertensive and analgetic activities [6]. With this in mind and with the purpose of carrying out pharmacological investigations we have carried out the synthesis of novel derivatives of(More)
Pyrazidol, which is chemically 2,3, 3a, 4, 5, 6-hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k] carbazole hydrochloride (international name pirlindole) administered repeatedly (21 days) to rats at a dose of 25 mg/kg per os maintained the selectivity of its inhibitory effect toward type A MAO. When administered repeatedly the inhibitory effect of pyrazidol was(More)
The experiments on albino rats demonstrated that antidepressants pyrazidol, imipramine, incazane, moclobemide and to a lesser degree azaphen reduce the amnesic effects of electroshock and scopolamine in the rats with the acquired conditioned reaction of passive avoidance. The studied antidepressants decrease also the disturbing action of alcohol on the(More)