MD Stringer

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It is well-established that severe, acute episodes of hypoxemia can damage the brain before birth, but the effects of more sustained hypoxemia are less well understood. We have used fetal fetal sheep in a series of studies aimed at determining the effects of prolonged hypoxemia, induced by placental insufficiency of differing severity and duration, on fetal(More)
Our aim was to test the hypothesis that a brief episode of hypoxemia near mid-gestation in fetal sheep will result in damage to the fetal brain with the extent and type of damage in any particular region being related to the developmental processes occurring at the time of the insult. Hypoxemia was induced, sufficient to reduce arterial O2 content by(More)
Nitric oxide synthase (NOS) is widely distributed throughout the nervous system and is found in neurons which produce nitric oxide (NO). In attempting to elucidate the biological roles of NO in neurotransmission, vasodilation, and in neurodegeneration, nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) histochemistry has been widely used.(More)
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