MD Hiroshi Inoue PhD

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Expression of activin A is associated with lymph node metastasis and clinical stage in esophageal cancer. To clarify the aggressive behavior of tumors with high activin A expression, we used the β subunit of activin A to establish stable activin βA (Act-βA)-transfected carcinoma cells in two human esophageal carcinoma cell lines, KYSE110 and KYSE140. The(More)
Background: Platelet-derived endothelial cell growth factor (PD-ECGF), whose expression is increased in several cancers, is an endothelial cell mitogen and has chemotactic activity in vitro and angiogenic activity in vivo. Tumors with high PD-ECGF expression tend to have frequent lymph node metastasis and are associated with poor outcome. Methods: We(More)
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