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INTRODUCTION Many doctors believe that patients with gout are unwilling to receive urate-lowering therapy (ULT) and blame them for poor adherence to management. OBJECTIVE To test the effectiveness of a complex intervention for gout that incorporates key elements of current guidelines, including full patient information, delivered in an optimal setting(More)
A model of cutaneous leishmaniasis using 10(2) Leishmania major metacyclic promastigotes inoculated into the footpads of genetically resistant C57BL/6 mice was studied in order to more accurately reproduce the evolution of lesion formation and the kinetics of parasite growth and immune response as they might occur in naturally exposed reservoirs and in(More)
Medical records of 20 dogs with gunshot fractures were reviewed to determine the prevalence of preoperative contamination and postoperative osteomyelitis. Fractures were repaired primarily by application of a bone plate (n = 16) or external fixator (n = 2) in buttress fashion or application of interfragmentary screws and pins (n = 2). In 17 dogs, an(More)
OBJECTIVE To examine whether beta2-adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle can modulate the severity of osteoarthritis (OA) in the rodent meniscectomy (MNX) model. METHODS Male Lewis rats were subcutaneously administered with 1.5 mg/kg/day clenbuterol hydrochloride (n=15) or saline vehicle (n=20) for 14 days. Following(More)
Studies of the nonpharmacologic treatment of osteoarthritis (OA) have fallen behind that of pharmacologic therapy for a variety of reasons. The design of studies that involve a therapist-delivered physical intervention presents several problems with respect to patient and observer blinding, the beneficial effect of therapist contact alone, and separation of(More)
Therapy with high-dose carboplatin plus etoposide-based chemotherapy plus autologous bone marrow rescue (AUBMR) was administered to 29 patients with advanced germ cell tumors (GCT) refractory to cisplatin-based chemotherapy. Two groups of patients with refractory disease were treated. Sixteen patients had been identified as "poor risk" at diagnosis and had(More)
Thirty adult patients with acute myelogenous leukemia (AML) in remission were treated with hyperfractionated total body irradiation, VP-16, and cyclophosphamide followed by infusion of autologous bone marrow purged with 4-hydroperoxycyclophosphamide and VP-16. Fifteen patients were transplanted in first remission (R1), 13 in second remission (R2), and two(More)
Ingestion of foreign bodies and self-mutilation by individuals with personality disorders and low intelligence are well documented in the literature. We describe a patient with these behaviour patterns and discuss aspects of diagnosis, surgical management and cost of treatment over a six year period. CASE HISTORY. The patient is a thirty-seven year old(More)