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The ligand-dependent nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the differentiation of several tissues and cell types. PPARgamma was recently determined to be essential for murine placental development and differentiation. We therefore assessed the influence of PPARgamma on differentiation of human placental(More)
The ligand-dependent nuclear receptor PPAR␥ plays an important role in murine and human trophoblast differentiation. Oxidized lipids, which are implicated in the pathophys-iology of placental dysfunction, have recently been identified as ligands for PPAR␥. We therefore hypothesized that oxidized lipids activate PPAR␥ in human trophoblasts and influence(More)
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