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The acceptability of prenatal diagnosis (PND) of sickle cell anaemia (SCA) as a means of controlling sickle cell disorder in Nigeria was examined using a structured questionnaire. The respondents were comprised of 92 adult female patients with SCA, aged 15-20 (23 +/- 6) years; 53 HbAS mothers, aged 20-61 (37 +/- 11) years and 48 HbAS fathers, aged 33-65 (46(More)
Background In comparison to the western world, aggressive non-Hodgkin's lymphoma (NHL) including primary central nervous system (CNS) lymphoma, as AIDS-defining disease , is less common in sub-Saharan Africa even with its high HIV/AIDS prevalence. We studied the occurrence of HIV/AIDS-related lymphomas in Nigerian patients with a view toward highlighting(More)
WHAT IS KNOWN AND OBJECTIVE Imatinib mesylate is the first-line drug for the treatment of Philadelphia/bcr-abl positive chronic myeloid leukaemia (CML). It is known to be metabolized mostly by CYP3A4 and CYP3A5 isoforms while its efflux is mediated by the transporters ABCB1 and ABCG2. Genetic polymorphism of some of these enzymes and transporters have been(More)
In this pioneering effort on Nigerians, the arithmetic means, ranges, and standard deviations for the concentrations of the 13 elements, Br, Ca, Cl, Cu, Fe, K, Na, P, Pb, Rb, S, Se, and Zn, detected in freeze-dried whole blood, erythrocytes, and plasma of 120 subjects drawn from different geographical regions of Nigeria are reported. Elemental analyses have(More)
A clinical and electroencephalographic study of the prevalence and pattern of epileptic seizures in 96 patients with sickle-cell anaemia (M:F 1:1, median age 12 years, range 2-45 years) attending our hospital is reported. Ten patients (M:F 1:1.5, median age 21 years, range 16-25 years) had epileptic seizures, giving a relatively high prevalence of 10.4%. Of(More)
This prospective study was aimed at determining the contribution of blood transfusion to paediatric HIV infection in Ile-lfe, Nigeria. It involved HIV screening of consecutive children presenting at the Obafemi Awolowo University Teaching Hospital (OAUTH), Ile-Ife, between March 1996 and March 2001, with any of the signs in the WHO clinical case definition(More)
Total lymphocyte count (TLC) has been recommended as a substitute for CD4 cell count for the management of HIV-infected individuals living in resource-limited settings. To confirm this, 151 TLCs and CD4 cell counts were obtained from 109 patients who had not yet started treatment and analyzed. CD4 cell counts of <200 cells/mm3 were found in 42 cases (37.8%)(More)
Blood lead levels were analysed and pulmonary function tests were performed on Nigerian traffic wardens, comprising sixty from Lagos (ages 24-52 years; 27 +/- 6), thirteen from the sparsely populated university town of Ile-Ife (ages 22-40 years; 27 +/- 8) and a control group of twenty-four subjects (age 19-55 years; 31 +/- 8). Perkin-Elmer Zeeman 3030/HGA(More)
OBJECTIVES Aspirin and selenium have been shown in vitro and in vivo to inhibit HIV production through inhibition of the transcription factor, the nuclear factor kappa binding (NF-eB). The aim of this study was to examine the efficacy or otherwise of these drugs in people living with HIV and AIDS (PLWAS) in resource limited countries. PATIENTS AND METHODS(More)
OBJECTIVES To determine the clinical features, modes of transmission and outcome of HIV infection in children. DESIGN A descriptive study involving prospective HIV antibody screening. SETTING Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria, a referral centre. SUBJECTS Four hundred and one consecutive children aged three days to 17 years(More)