• Publications
  • Influence
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
TLDR
The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement. Expand
Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs
TLDR
The structural diversity and wide-ranging potencies of the analogs described herein provide the opportunity to develop a pharmacophore for the cannabinoids using molecular modeling techniques. Expand
The cannabinoid receptor: biochemical, anatomical and behavioral characterization
TLDR
The actions of the active principle of marihuana, delta 9-tetrahydrocannabinol, are mimicked by synthetic cannabinoid agonists showing high potency and enantio-selectivity in behavioral assays, leading to a better understanding of the effects of cannabinoids in the CNS of humans and experimental animals. Expand