Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine.
- M. Tepel, M. van der Giet, C. Schwarzfeld, U. Laufer, D. Liermann, W. Zidek
- MedicineNew England Journal of Medicine
- 20 July 2000
Prophylactic oral administration of the antioxidant acetylcysteine, along with hydration, prevents the reduction in renal function induced by contrast agents in patients with chronic renal insufficiency.
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
- J. Nofer, M. van der Giet, B. Levkau
- Biology, ChemistryJournal of Clinical Investigation
- 15 February 2004
HDL is identified as a carrier of bioactive lysophospholipids that regulate vascular tone via S1P3-mediated NO release and induces vasodilation in isolated aortae via intracellular Ca2+ mobilization and Akt-mediated eNOS phosphorylation.
Two Novel Equations to Estimate Kidney Function in Persons Aged 70 Years or Older
- E. Schaeffner, Natalie Ebert, P. Martus
- MedicineAnnals of Internal Medicine
- 2 October 2012
The BIS2 equation should be used to estimate GFR in persons aged 70 years or older with normal or mild to moderately reduced kidney function, and if cystatin C is not available, the BIS1 equation is an acceptable alternative.
Diabetes mellitus type 2 in urban Ghana: characteristics and associated factors
- I. Danquah, G. BeduâAddo, F. Mockenhaupt
- MedicineBMC Public Health
- 20 March 2012
DM2 affects predominantly obese patients of rather low socio-economic status and frequently is accompanied by hypertension and hyperlipidaemia and prevention and management need to account for a specific risk profile in this population.
Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1âphosphate
- C. Bode, SvenâChristian Sensken, M. Gräler
- Biology, MedicineJournal of Cellular Biochemistry
- 15 April 2010
RBCâassociated S1P has two functions: (1) It contributes to the cellular pool of SGPL1âsensitive S 1P in tissues after transcellular transportation and (2) it helps maintain extracellular S1p levels via SA and HDL independently fromSGPL1 activity.
A new oscillometric method for pulse wave analysis: comparison with a common tonometric method
- S. Wassertheurer, J. Kropf, D. Magometschnigg
- MedicineJournal of Human Hypertension
- 18 March 2010
The ARCSolver method is a novel method determining AIx and aSBP based on an oscillometric system with a cuff that is easy and for widespread use and the results agree with common accepted tonometric measurements.
The Antioxidant Acetylcysteine Reduces Cardiovascular Events in Patients With End-Stage Renal Failure: A Randomized, Controlled Trial
- M. Tepel, M. van der Giet, M. Statz, J. Jankowski, W. Zidek
- MedicineCirculation
- 25 February 2003
In hemodialysis patients, treatment with acetylcysteine (600 mg BID), a thiol-containing antioxidant, reduces composite cardiovascular end points.
CKD: A Call for an Age-Adapted Definition.
- P. Delanaye, K. Jager, J. van den Brand
- MedicineJournal of the American Society of Nephrology
- 2019
It is suggested that the CKD definition be amended to include age-specific thresholds for GFR, as it is found that GFR declines with healthy aging without any overt signs of compensation (such as elevated single-nephron GFR) or kidney damage.
Serum amyloid A in uremic HDL promotes inflammation.
- T. Weichhart, C. Kopecky, M. Säemann
- Biology, MedicineJournal of the American Society of Nephrology
- 1 May 2012
It is observed that HDL isolated from healthy individuals inhibited the production of inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist, suggesting a potential link between the high levels of inflammation and cardiovascular mortality in uremia.
The Sphingosine-1-Phosphate Analogue FTY720 Reduces Atherosclerosis in Apolipoprotein EâDeficient Mice
- P. Keul, M. TĂślle, B. Levkau
- Biology, MedicineArteriosclerosis, Thrombosis and Vascular Biology
- 1 March 2007
It is suggested that FTY720 inhibits atherosclerosis by suppressing the machinery involved in monocyte/macrophage emigration to atherosclerotic lesions as S1P agonists that selectively target the vasculature and not the immune system may be promising new drugs against Atherosclerosis.
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