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Delivering affordable cancer care in high-income countries.
TLDR
Urgent solutions range from re-engineering of the macroeconomic basis of cancer costs (eg, value-based approaches to bend the cost curve and allow cost-saving technologies), greater education of policy makers, and an informed and transparent regulatory system. Expand
Prognostic value of histopathology and trends in cervical cancer: a SEER population study
TLDR
The incidental observation of increasing numbers of adenocarcinomas despite a general decline suggests the inefficiency of conventional screening for these tumors, and the need to identify women who are at risk. Expand
Stromal contribution to the colorectal cancer transcriptome
TLDR
Analysis of CRC expression data from patient-derived xenografts shows that the distinctive transcriptional and clinical features of the SSM subtype can be ascribed to its particularly abundant stromal component. Expand
Prospective, risk-adapted strategy of stereotactic body radiotherapy for early-stage non-small-cell lung cancer: results of a Phase II trial.
TLDR
The proposed risk-adapted strategy for both centrally and peripherally located lesions showed an acceptable toxicity profile while maintaining excellent local control rates, and the correlation between local control and tumor diameter calls for the inclusion of tumor stage as a variable in future study design. Expand
Phase II study of stereotactic body radiotherapy to primary tumor and metastatic locations in oligometastatic nonsmall-cell lung cancer patients.
TLDR
SBRT to all disease sites, primary tumor and metastatic locations, in oligometastatic NSCLC patients produced an acceptable median PFS of 11.2 months, according to PET Response Criteria in Solid Tumors (PERCIST). Expand
Dosimetric comparison of different treatment modalities for stereotactic radiosurgery of arteriovenous malformations and acoustic neuromas.
TLDR
Gamma-Knife-Perfexion will comply with all SRS constraints (high conformity while minimizing low-dose spread) and inverse planning and modulated fluences (Novalis-Tx-DMLC-IMRT and CyberKnife) will deliver the most homogeneous treatment. Expand
A (short) history of image-guided radiotherapy.
TLDR
Recent developments in improved IT infrastructures, novel irradiation techniques, and better knowledge of functional and morphologic information may have created the need and optimal environment to revive the interest in IGRT. Expand
Geometric accuracy of a novel gimbals based radiation therapy tumor tracking system.
TLDR
In terms of dynamic behavior, the gimbaled linac of the VERO system showed to be an excellent approach for providing accurate real-time tumor tracking in radiation therapy. Expand
Initial assessment of tumor tracking with a gimbaled linac system in clinical circumstances: a patient simulation study.
TLDR
The Vero tracking solution proved to be fully functional and showed performance comparable with other real-time tracking systems. Expand
Clinical evaluation of a robotic 6-degree of freedom treatment couch for frameless radiosurgery.
TLDR
The 6 DOF patient positioning with a 6DOF robotic couch to correct translational and rotational setup errors improves target positioning with respect to treatment isocenter, which is in direct relation with the clinical outcome, compared with the 4DOF positioning. Expand
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