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GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al.… Expand
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Leveraging phased haplotypes… Expand
Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X.
CONTEXT Approximately 60% of families that meet the Amsterdam-I criteria (AC-I) for hereditary nonpolyposis colorectal cancer (HNPCC) have a hereditary abnormality in a DNA mismatch repair (MMR)… Expand
High-resolution whole-genome association study of Parkinson disease.
- D. Maraganore, M. de Andrade, +7 authors D. Ballinger
- Biology, Medicine
- American journal of human genetics
- 1 November 2005
We performed a two-tiered, whole-genome association study of Parkinson disease (PD). For tier 1, we individually genotyped 198,345 uniformly spaced and informative single-nucleotide polymorphisms… Expand
A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease
While major inroads have been made in identifying the genetic causes of rare Mendelian disorders, little progress has been made in the discovery of common gene variations that predispose to complex… Expand
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for… Expand
Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy.
- Katharine M Brauch, Margaret L. Karst, +5 authors T. Olson
- Journal of the American College of Cardiology
- 1 September 2009
OBJECTIVES We sought to identify a novel gene for dilated cardiomyopathy (DCM). BACKGROUND DCM is a heritable, genetically heterogeneous disorder that remains idiopathic in the majority of… Expand
Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.
Base excision repair and nucleotide excision repair are vital responses to multiple types of DNA damage, including damage from tobacco exposure. Single-nucleotide polymorphisms (SNP) in these… Expand
Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer.
BACKGROUND & AIMS The temporal association between diabetes mellitus and pancreatic cancer is poorly understood. We compared temporal patterns in diabetes prevalence in pancreatic cancer and… Expand
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.
CONTEXT Identification and replication of susceptibility genes for Parkinson disease at the population level have been hampered by small studies with potential biases. Alpha-synuclein (SNCA) has been… Expand