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Caulosegnins I-III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster.
The structure of the most abundant lasso peptide caulosegnin I is elucidated via NMR spectroscopic analysis and a thorough mutational analysis is performed that gave insight into their biosynthesis and revealed important factors affecting the stabilization of the lasso fold in general. Expand
The astexin-1 lasso peptides: biosynthesis, stability, and structural studies.
A new lasso structure with a tight loop and long tail as well as narrow specificity of the maturation machinery for some essential residues associated with the protease processing site, involved in macrolactam ring formation and entrapment of the tail is revealed. Expand
Lasso peptides: an intriguing class of bacterial natural products.
The newest findings about the lasso peptides, an emerging class of ribosomally assembled and post-translationally modified peptides from bacteria that were first described in 1991 are discussed and the general methodology to elucidate these structures by NMR will be discussed and pitfalls for these approaches are highlighted. Expand
Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry.
A B protein-centric genome mining approach is demonstrated through which it is able to identify 102 putative lasso peptide biosynthetic gene clusters from a total of 87 different proteobacterial strains. Expand
How to get rid of mitochondria: crosstalk and regulation of multiple mitophagy pathways
The current state of knowledge about these multiple pathways, which include receptor-mediated and ubiquitin-mediated mitophagy, are summarized, and the regulation and crosstalk between these pathways are described. Expand
Xanthomonins I-III: a new class of lasso peptides with a seven-residue macrolactam ring.
Lasso peptides belong to the class of ribosomally synthesized and post-translationally modified peptides. Their common distinguishing feature is an N-terminal macrolactam ring that is threaded by theExpand
Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin*
The study reveals how lasso peptides are chemically diversified and sets the foundation for rational engineering of these intriguing natural products. Expand
Characterization of caulonodin lasso peptides revealed unprecedented N-terminal residues and a precursor motif essential for peptide maturation
Lasso peptides, a peculiar family of ribosomally assembled and post-translationally modified peptides (RiPPs), possess a fascinating 3D structure, which can confer rigidity and stability againstExpand
Controlling quality and amount of mitochondria by mitophagy: insights into the role of ubiquitination and deubiquitination
How ubiquitination and deubiquitination regulates mitophagy and other selective forms of autophagy is discussed and what argues for using baker’s yeast as a model to study the ubiquitin-dependentMitophagy pathway is argued for. Expand
Analytical methods for the characterization and quality control of pharmaceutical peptides and proteins, using erythropoietin as an example.
A combination of several analytical methods is necessary for a comprehensive characterization of the substance under investigation and for an appropriate quality control of the product concerning identity, purity and potency. Expand