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Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A.
Immunosuppressive properties of six tyrosine analogues of cyclolinopeptide A were studied and compared with the activity of cyclosporin A. The peptides were investigated using PFC (in vitro) and DTHExpand
Immunosuppressive analogues of hexapeptide Tyr-Val-Pro-Leu-Phe-Pro, an immune system stimulant.
Results suggest that simultaneous presence of both Val2 and Leu4 residues is necessary for the generation of immunostimulation, and competition in biological effects observed for I and III in PFC in vitro test suggests that these analogues may interact with the same cellular receptor. Expand
Immunosuppressive activity in the series of cycloamanide peptides from mushrooms
The immunosuppressor activity of the cycloamanides A, B, C, and D, and two of their D-amino acid residue-containing analogues, was examined using PFC and DTH tests and it was found thatcycloamanide A (CyA A, II) and its D-Phe-containing analogue III are the most potent Immunosuppressors of the whole series. Expand
The unusually high immunomodulatory activity of thymopentin analogue Pro5-TP-5.
Pro5-TP-5 showed very strongly enhanced activity as compared with TP-5; the effect is especially well obvious in PFC in vitro (15-fold enhancement of activity). Expand
Effect of proline-rich polypeptide on experimental autoimmune response to erythrocytes.
The number of ARFC among non-B lymphocytes in peripheral blood was increased in mice immunized with RRBC compared to those in non-immunized animals and the numbers after thymectomy and/or PRP treatment were in opposition to those of the intensity of AEAP in the respective experimental groups. Expand
Differentiation of T cells into helper cells from immature precursors: identification of a target cell for a proline-rich polypeptide (PRP).
We demonstrated, with the aid of PRP, that precursors of helper T cells in the humoral immune response to SRBC belong to a minor thymocyte subset bearing the: Thy-1 +/-, H-2+, L3T4-, lyt 2-, CD3-Expand
Interleukin-1 decreases the level of thymocytes forming rosettes with autologous erythrocytes: a new method of determination of interleukin-1 activity.
It was demonstrated that human, recombinant Il-1 significantly inhibited formation of autologous rosettes by thymocytes. In addition, Il-1 increased the percentage of thymocytes resistant toExpand
Immunosuppressive activity of antamanide and some of its analogues
Investigation of immunosuppressive properties of antamanide and a number of its analogues, including symmetrical antamanides, and compared them with the activities of cyclosporin A and CLA found them to be weaker than CLA. Expand
Immunosuppressive activity of analogs of tripeptide Lys-Arg-Pro with D-amino acid residues.
It was found that incorporation of D-amino acid residues in definite positions of the peptide chain gives the substances with immunosuppressive activity. Expand