M. Zigmond

Publications355
h-index73
Citations23,153
Highly Influential Citations878
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Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
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Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex
TLDR
Microdialysis was used to assess extracellular dopamine in striatum, nucleus accumbens, and medial frontal cortex of unanesthetized rats both under resting conditions and in response to intermittent tail‐shock stress, providing direct in vivo evidence for the global activation of dopaminergic systems by stress.
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Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine
TLDR
Results suggest that physical therapy may be beneficial in Parkinson's disease and show remarkable sparing of striatal DA, its metabolites, and the expression of the vesicular monoamine transporter, suggesting a decrease in the extent of DA neuron degeneration.
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A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
TLDR
Data suggest that α-synuclein plays a role in the regulation of dopamine biosynthesis, acting to reduce the activity of tyrosine hydroxylase.
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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.
TLDR
D dopamine in high concentrations binds to protein in the striatum, an event that is correlated with the specific loss of dopaminergic terminals in Parkinson's disease, and is suggested to be caused by an imbalance between the oxidation of dopamine and the availability of antioxidant defenses.
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Increased dopamine and norepinephrine release in medial prefrontal cortex induced by acute and chronic stress: Effects of diazepam
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A role for alpha-synuclein in the regulation of dopamine biosynthesis.
TLDR
Data suggest that alpha-synuclein plays a role in the regulation of dopamine biosynthesis, acting to reduce the activity of tyrosine hydroxylase.
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Compensations after lesions of central dopaminergic neurons: some clinical and basic implications
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Stress‐Induced Sensitization of Dopamine and Norepinephrine Efflux in Medial Prefrontal Cortex of the Rat
TLDR
Both cortical NE projections and cortically projecting DA neurons sensitize after chronic exposure to cold, in contrast, subcortical DA projections do not sensitize under these conditions.
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Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF
TLDR
It is suggested that preinjury forced limb‐use can prevent the behavioral and neurochemical deficits to the subsequent administration of 6‐OHDA and that this may be due in part to neuroprotective effects of GDNF.
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