• Publications
  • Influence
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the Polycomb groupExpand
  • 1,179
  • 80
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind specifically modified histones: the mechanisms ofExpand
  • 331
  • 36
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of She complexed to a phosphopeptide reveals an alternative means of recognizing tryosine-phosphorylated proteins.Expand
  • 371
  • 28
Structure and regulation of MAPK phosphatases.
MAP kinases (MAPKs), which control mitogenic signal transduction in all eukaryotic organisms, are inactivated by dual specificity MAPK phosphatases (DS-MKPs). Recent studies reveal that substrateExpand
  • 433
  • 26
  • PDF
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
ABSTRACT Acetylation of the RelA subunit of NF-κB, especially at lysine-310, is critical for the transcriptional activation of NF-κB and the expression of inflammatory genes. In this study, weExpand
  • 387
  • 26
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a mechanism by which Twist recruits BRD4 toExpand
  • 281
  • 20
Mechanism and Regulation of Acetylated Histone Binding by the Tandem PHD Finger of DPF3b
Histone lysine acetylation and methylation have an important role during gene transcription in a chromatin context. Knowledge concerning the types of protein modules that can interact withExpand
  • 262
  • 18
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Lysine acetylation of the tumor suppressor protein p53 in response to a wide variety of cellular stress signals is required for its activation as a transcription factor that regulates cell cycleExpand
  • 285
  • 15
  • PDF
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.
The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated by members of the Polycomb group (PcG) of transcriptional repressors. Here we show that signaling fromExpand
  • 309
  • 14
Reading protein modifications with interaction domains
Proteins are controlled by a vast and dynamic array of post-translational modifications, many of which create binding sites for specific protein-interaction domains. We propose that these domains,Expand
  • 624
  • 13