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Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the Polycomb group… Expand
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.
Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind specifically modified histones: the mechanisms of… Expand
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of She complexed to a phosphopeptide reveals an alternative means of recognizing tryosine-phosphorylated proteins.… Expand
Structure and regulation of MAPK phosphatases.
MAP kinases (MAPKs), which control mitogenic signal transduction in all eukaryotic organisms, are inactivated by dual specificity MAPK phosphatases (DS-MKPs). Recent studies reveal that substrate… Expand
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
- Bo Huang, Xiao-dong Yang, M. Zhou, K. Ozato, L. Chen
- Biology, Medicine
- Molecular and Cellular Biology
- 22 December 2008
ABSTRACT Acetylation of the RelA subunit of NF-κB, especially at lysine-310, is critical for the transcriptional activation of NF-κB and the expression of inflammatory genes. In this study, we… Expand
Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene expression. Here we report a mechanism by which Twist recruits BRD4 to… Expand
Mechanism and Regulation of Acetylated Histone Binding by the Tandem PHD Finger of DPF3b
Histone lysine acetylation and methylation have an important role during gene transcription in a chromatin context. Knowledge concerning the types of protein modules that can interact with… Expand
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.
Lysine acetylation of the tumor suppressor protein p53 in response to a wide variety of cellular stress signals is required for its activation as a transcription factor that regulates cell cycle… Expand
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS.
The INK4a/ARF tumor suppressor locus, a key executor of cellular senescence, is regulated by members of the Polycomb group (PcG) of transcriptional repressors. Here we show that signaling from… Expand
Reading protein modifications with interaction domains
- B. Seet, I. Dikic, M. Zhou, T. Pawson
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 July 2006
Proteins are controlled by a vast and dynamic array of post-translational modifications, many of which create binding sites for specific protein-interaction domains. We propose that these domains,… Expand