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The polycomb group protein EZH2 is involved in progression of prostate cancer
TLDR
Dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent prostate cancer from those at risk of lethal progression. Expand
The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia
TLDR
The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors, with consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system. Expand
Androgen-Independent Prostate Cancer Is a Heterogeneous Group of Diseases
TLDR
Metastatic hormone-refractory prostate cancer has a heterogeneous morphology, immunophenotype, and genotype, demonstrating that “metastatic disease” is a group of diseases even within the same patient. Expand
Clear Cell Tubulopapillary Renal Cell Carcinoma: A Study of 36 Distinctive Low-grade Epithelial Tumors of the Kidney
TLDR
It is shown that these tumors, which are term as “clear cell tubulopapillary renal cell carcinoma,” constitute a unique subtype in the spectrum of renal epithelial neoplasia based on their characteristic morphologic and immunohistochemical features. Expand
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.
TLDR
It is identified that fumarate can directly up-regulate antioxidant response element (ARE)-controlled genes and is up-regulated upon FH knockdown as well as in FH null cell lines, and AKR1B10 overexpression is also a prominent feature in both hereditary and sporadic PRCC2. Expand
Fibroblast growth factor 2 control of vascular tone
TLDR
It is shown that a well-known growth factor, FCF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control. Expand
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma.
TLDR
IL-8 is revealed as an important contributor to sunitinib resistance in ccRCC and a candidate therapeutic target to reverse acquired or intrinsic resistance to sun itinib in this malignancy. Expand
Mtr4-like Protein Coordinates Nuclear RNA Processing for Heterochromatin Assembly and for Telomere Maintenance
TLDR
A nuclear RNA-processing network in fission yeast with a core module comprising the Mtr4-like protein, Mtl1, and the zinc-finger protein, Red1 is described, revealing unique cellular strategies for recognizing regulatory RNAs and coordinating their functions in response to developmental and environmental cues. Expand
miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma
TLDR
The present study found that miR-216b was downregulated in nasopharyngeal carcinoma (NPC) cell lines and specimens and demonstrated that it can bind to the 3′ untranslated region (UTR) of KRAS and inhibit expression of the KRAS protein. Expand
Crystal structure of a potassium ion transporter TrkH
TLDR
The crystal structure of a TrkH from Vibrio parahaemolyticus is presented, revealing the molecular basis of K+ selectivity and suggesting a novel gating mechanism for this large and important family of membrane transport proteins. Expand
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