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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity.
Posttranslational modification of autophagy-related proteins in macroautophagy
Unraveling how these PTMs regulate ATG protein function during macroautophagy will not only reveal fundamental mechanistic insights into the regulatory process, but also provide new therapeutic targets for the treatment of autophagy-associated diseases.
EphA2 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells
Overexpression of EphA2 resulted in the upregulation of the EMT molecular markers N-cadherin and Snail, as well as the Wnt/β-catenin targets TCF4, Cyclin-D1 and c-Myc, while silencing Eph a2 using short hairpin RNA had the opposite effect.
Alterations of microRNAs in Cisplatin-resistant Human Non-small Cell Lung Cancer Cells (A549/DDP)
- Qi Wang, M. Zhong, Wei Liu, Jianhuang Li, Jin Huang, Le Zheng
- BiologyExperimental lung research
- 12 August 2011
Findings suggest that miR-138 could play an important role in the development of cisplatin resistance in non-small cell lung cancer (NSCLC) through up- and down-regulation of miRNAs.
MicroRNA-429 inhibits the migration and invasion of colon cancer cells by targeting PAK6/cofilin signaling.
- Xiangyang Tian, Zibai Wei, Jia Wang, Ping Liu, Yijun Qin, M. Zhong
- Biology, ChemistryOncology reports
- 1 August 2015
The results of the present study suggested that miR-429 inhibits the migration and invasion of colon cancer cells, partly at least, by mediating the expression of PAK6, as well as the activity of cofilin signaling.
Case-control study of single nucleotide polymorphisms of PSCA and MUC1 genes with gastric cancer in a Chinese.
- Fang Li, M. Zhong, Jian-huang Li, Wei Liu, B. Li
- Biology, MedicineAsian Pacific journal of cancer prevention…
The study suggested rs2294008 in the PSCA gene to be associated with increased risk of gastric cancer and rs2070803 in MUC1 to play a protective role in a Chinese population.
Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway
Results indicated that leptin could regulate proliferation and apoptosis of colorectal carcinoma through the PI3K/Akt/mTOR signalling pathway.
Exosome-derived miRNAs as predictive biomarkers for diffuse large B-cell lymphoma chemotherapy resistance.
ExosomalmiR-99a-5p and miR-125b- 5p can serve as biomarkers for DLBCL and can predict chemotherapeutic efficacy, according to the results.
High expression of Toll-like receptor 5 correlates with better prognosis in non-small-cell lung cancer: an anti-tumor effect of TLR5 signaling in non-small cell lung cancer
- Hui Zhou, Jian-hua Chen, M. Zhong
- Biology, MedicineJournal of Cancer Research and Clinical Oncology
- 19 February 2014
It is demonstrated that activation of TLR5 by flagellin in NSCLC cells inhibited cell proliferation, migration, and invasion in vitro, and may serve as a potential therapeutic target inNSCLC patients.