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Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder: A Positron Emission Tomography Study
TLDR
It is suggested that abnormal CB1 receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder. Expand
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
TLDR
A unique approach to controlled delivery in the brain should have a significant impact on treatment of glioblastoma multiforme and suggests previously undescribed routes for drug and gene delivery to treat other diseases of the central nervous system. Expand
Carbon-11-thymidine and FDG to measure therapy response.
TLDR
In this limited series, K(TdR) measurements showed a complete shutdown in tumor proliferation in patients in whom FDG showed a more limited decrease in glucose metabolism. Expand
Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist
TLDR
PET can be used to image and quantify KOR in humans, although it has slow kinetics and variability of model-derived kinetic parameters is higher than desirable and this tracer should be suitable for use in receptor occupancy studies, particularly those that target high occupancy. Expand
PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F]ASEM in humans
TLDR
These results confirm [18F]ASEM as a suitable radiotracer for the imaging and quantification of α7 nAChRs in humans and confirm the test-retest variability of VT was assessed. Expand
Development of labeled thymidine analogs for imaging tumor proliferation.
TLDR
Of the three thymidine analogs tested, only FFUdR showed preferential retention in rapidly proliferating tissues, such as the spleen and implanted tumors, and it attained tissue to blood ratios of 2.1 at 2 h. Expand
Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology.
TLDR
Results of this study suggest that KOR availability in an amygdala-anterior cingulate cortex-ventral striatal neural circuit mediates the phenotypic expression of trauma-related loss (ie, dysphoria) symptoms and suggest that an activated corticotropin-releasing factor/hypothalamic-pituitary-adrenal axis system may indirectly mediate this association. Expand
Synthesis and Evaluation of 11C-LY2795050 as a κ-Opioid Receptor Antagonist Radiotracer for PET Imaging
TLDR
This newly developed KOR antagonist tracer has since been advanced to PET imaging of KOR in humans and constitutes the first successful KOR antagonists radiotracer. Expand
Relationship Between Glycine Transporter 1 Inhibition as Measured with Positron Emission Tomography and Changes in Cognitive Performances in Nonhuman Primates
TLDR
The results confirm the efficacy of this mechanism to correct working memory deficits associated with NMDA hypofunction and suggest the existence of an inverted-U dose–response curve in the potential therapeutic effect of this class of compounds. Expand
Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor
TLDR
The results suggest that quantification of 11C-LY2795050 imaging is reproducible and reliable in regions with moderate and high KOR density and therefore this first antagonist radiotracer is highly useful for PET studies of KOR. Expand
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