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Bone Morphogenetic Proteins
Preclinical and clinical studies have shown that BMP-2 can be utilized in various therapeutic interventions such as bone defects, non-union fractures, spinal fusion, osteoporosis and root canal surgery. Expand
Bone Morphogenetic Protein 2 Induces Dental Follicle Cells to Differentiate Toward a Cementoblast/Osteoblast Phenotype
The results suggest that BMP‐2 triggers follicle cells to differentiate toward a cementoblast/osteoblast phenotype and that the MAPK pathway is involved. Expand
Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo.
Ex vivo Runx2 gene transfer may be an effective route to enhance the osteogenic potential of MSCs, and time-course studies indicate that Runx 2-dependent mineralization persisted for the duration of the experiment. Expand
Combinatorial gene therapy for bone regeneration: Cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7
Testing the hypothesis that gene therapy‐based bone regeneration can be enhanced by expressing combinations of BMPs shows that dramatic enhancement of osteogenesis can be achieved using gene therapy to express specific combinations of interacting regenerative molecules. Expand
Signal transduction and biological functions of bone morphogenetic proteins.
Bone morphogenetic proteins are multi-functional growth factors and belong to the transforming growth factor beta (TGFbeta) superfamily and it has been shown that BMPs play critical roles in mesoderm formation, heart development, cartilage development and postnatal bone formation. Expand
Growth Regulatory Factors and Bone
This work has shown that the availability of these growth regulatory factors at the resorption site has important implications not only for bone remodeling in the formation phase of the normal remodeling process, but also possibly for the repair of bone following fracture or injury. Expand
Exploring the Origins of Cementoblasts and their Trigger Factors
Study here focused on determining the responsiveness of putative cementoblast progenitor cells, periodontal ligament cells, and cementoblasts to specific factors, and found dissimilarities in responsiveness associated with cell type may need to be considered when designing regenerative therapies. Expand
Effect of sustained gene delivery of platelet-derived growth factor or its antagonist (PDGF-1308) on tissue-engineered cementum.
It is suggested that continuous exogenous delivery of PDGF-A may delay mineral formation induced by cementoblasts, while PDGF is clearly required for mineral neogenesis. Expand
MiR-125a-3p Regulates Glioma Apoptosis and Invasion by Regulating Nrg1
Findings suggest that miR-125a-3p performed an important role in glioma development mediated by directly regulating the expression of Nrg1 and provides a potential target for diagnosis and treatment of malignant gliomas. Expand
Repair of articular cartilage defects in rabbits through tissue-engineered cartilage constructed with chitosan hydrogel and chondrocytes
  • M. Zhao, Zhu Chen, +6 authors G. Feng
  • Chemistry, Medicine
  • Journal of Zhejiang University-SCIENCE B
  • 11 November 2015
The novel tissue-engineered cartilage constructed in this research can completely repair the structure of damaged articular cartilage. Expand