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Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potentExpand
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Deletion of the β2-adrenergic receptor prevents the development of cardiomyopathy in mice.
Beta adrenergic receptor (β-AR) subtypes act through diverse signaling cascades to modulate cardiac function and remodeling. Previous in vitro studies suggest that β1-AR signaling is cardiotoxicExpand
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Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis.
Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital generalized lipodystrophy (CGL). BSCL2 mRNA isExpand
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The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction.
Regeneration of the damaged myocardium is one of the most challenging fronts in the field of tissue engineering due to the limited capacity of adult heart tissue to heal and to the mechanical andExpand
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Irbesartan treatment up‐regulates hepatic expression of PPARα and its target genes in obese Koletsky (fak/fak) rats: a link to amelioration of hypertriglyceridaemia
Hypertriglyceridaemia is associated with an increased risk of cardiovascular disease. Irbesartan, a well‐established angiotensin II type 1 receptor (AT1) blocker, improves hypertriglyceridaemia inExpand
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Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice
Aims/hypothesisEvidence suggests that telmisartan, an angiotensin II type 1 receptor (AT1) blocker and peroxisome proliferator-activated receptor-γ partial agonist, has beneficial actions that limitExpand
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Physiologic and molecular characterization of a murine model of right ventricular volume overload.
Pulmonary insufficiency (PI) is a common long-term sequel after repair of tetralogy of Fallot, causing progressive right ventricular (RV) dilation and failure. We describe the physiologic andExpand
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RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
RATIONALE Pulmonary arterial hypertension is characterized by endothelial dysregulation, but global changes in gene expression have not been related to perturbations in function. OBJECTIVES RNAExpand
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Contributions of Leukocyte Angiotensin-Converting Enzyme to Development of Atherosclerosis
Objective—This study determined the role of angiotensin-converting enzyme (ACE) on the development of angiotensin I–induced atherosclerosis and the contribution of leukocyte-specific expression ofExpand
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Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes
Aims/hypothesisMore than 90% of Chinese familial early-onset type 2 diabetes mellitus is genetically unexplained. To investigate the molecular aetiology, we identified and characterised whetherExpand
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