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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
  • Wei Qi, H. Chan, +25 authors E. Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 10 December 2012
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) andExpand
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Redox signalling involving NADPH oxidase-derived reactive oxygen species.
Increased oxidative stress plays an important role in the pathophysiology of many diseases such as atherosclerosis, diabetes mellitus, myocardial infarction and heart failure. In addition to theExpand
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An HDAC2-TET1 switch at distinct chromatin regions significantly promotes the maturation of pre-iPS to iPS cells
The maturation of induced pluripotent stem cells (iPS) is one of the limiting steps of somatic cell reprogramming, but the underlying mechanism is largely unknown. Here, we reported that knockdown ofExpand
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Imbalance of Microglial TLR4/TREM2 in LPS-Treated APP/PS1 Transgenic Mice: A Potential Link Between Alzheimer’s Disease and Systemic Inflammation
Clinically, superimposed systemic inflammation generally has significant deleterious effects on the Alzheimer’s disease (AD) progression. However, the related molecular mechanisms remain poorlyExpand
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FLT3 pathway is a potential therapeutic target for PRC2-mutated T-cell acute lymphoblastic leukemia.
TO THE EDITOR: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, and T-cell ALL (T-ALL) accounts for approximately 15% of cases of childhood ALL.[1][1],[2][2] Early T-cellExpand
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Protective effects of anthocyanins from purple sweet potato on acute carbon tetrachloride-induced oxidative hepatotoxicity fibrosis in mice
ABSTRACT The present study was designed to evaluate the antioxidant activities of anthocyanins obtained from purple sweet potato (PSPAs) and their protective effect on hepatic fibrosis induced byExpand
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Study on Cellular Structures as the Core Architectures of Parts Based on Selective Laser Melting
Cellular structures exhibit favorable properties for multifunctional applications, such as light weight, high load-bearing combined with high heat exchange capability. This paper is to seek optimalExpand
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Liraglutide reduces lipid accumulation in steatotic L-02 cells by enhancing autophagy
Simple hepatic steatosis is the early stage of non-alcoholic fatty liver disease and is recognized as a benign process. Previous studies show that glucagon-like peptide-1 has great potential inExpand
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Resveratrol inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through AMPK activation.
BACKGROUND Resveratrol, a natural phenolic compound found in red grapes, has been reported to inhibit proliferation and induce apoptosis via regulation of AMPK signaling pathways in several cancerExpand
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The Roles of Testicular C-kit Positive Cells in De novo Morphogenesis of Testis
C-kit positive (c-kit+) cells are usual tissue-specific stem cells. However, in postnatal testis, undifferentiated spermatogonial stem cells (SSCs) are c-kit negative (c-kit−) and activation of c-kitExpand
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