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Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations.
Recent three genome-wide association studies have mapped a lung cancer susceptibility locus to chromosome 15q25 in Caucasians. However, the reported risk single nucleotide polymorphisms (SNPs) are… Expand
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up… Expand
Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women
Purpose: Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Th1 responses and thus participates in the carcinogenesis of human papillomavirus–related cervical… Expand
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and… Expand
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3
We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several… Expand
Use of tanning beds and incidence of skin cancer.
- M. Zhang, A. Qureshi, A. Geller, L. Frazier, D. Hunter, J. Han
- Journal of clinical oncology : official journal…
- 10 May 2012
PURPOSE We sought to evaluate the risk effect of tanning bed use on skin cancers among teenage and young adults. We also expected to determine whether a dose-response relationship was evident. … Expand
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
Aiming to identify novel genetic loci for pigmentation and skin cancer, we conducted a series of genome-wide association studies on hair color, eye color, number of sunburns, tanning ability and… Expand
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells
- X. Ni, Qingxiao Song, +9 authors D. Zeng
- Chemistry, Medicine
- The Journal of clinical investigation
- 11 May 2017
Programmed death ligand-1 (PD-L1) interacts with programmed death-1 (PD-1) and the immunostimulatory molecule CD80 and functions as a checkpoint to regulate immune responses. The interaction of PD-L1… Expand
Evaluation of genetic variants in microRNA biosynthesis genes and risk of breast cancer in Chinese women
- Y. Jiang, Jiaping Chen, +12 authors H. Shen
- Biology, Medicine
- International journal of cancer
- 1 November 2013
MicroRNAs (miRNA) are a class of small, noncoding RNA molecules involved in a diversity of cellular functions. Single nucleotide polymorphisms (SNPs) in miRNA biosynthesis genes may affect the… Expand
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes;… Expand