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Transcriptional regulation of the human sterol 12alpha-hydroxylase gene (CYP8B1): roles of heaptocyte nuclear factor 4alpha in mediating bile acid repression.
TLDR
The critical roles HNF4alpha play on CYP8B1 transcription and its repression by bile acids are revealed. Expand
Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain.
TLDR
The structures of the DLC8/target peptide complexes, together with the dynamic properties of the protein, provide a molecular basis of DLC8's diverse amino acid sequence-dependent target recognition. Expand
Structure of Tctex-1 and Its Interaction with Cytoplasmic Dynein Intermediate Chain*
TLDR
The experimental results presented in this study suggest that Tctex-1 is likely to be a specific cargo adaptor for the dynein motor complex. Expand
Cystatin E is a Novel Human Cysteine Proteinase Inhibitor with Structural Resemblance to Family 2 Cystatins*
TLDR
A strikingly high incidence of cystatin E clones in cDNA libraries from fetal skin epithelium and amniotic membrane cells indicates a protective role of cysteine proteinase inhibitor during fetal development. Expand
Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.
TLDR
Results support a model in which coordinate occupancy of the AP-1 sites in the VDRE and OC box in proliferating osteoblasts may suppress both basal level and vitamin D-enhanced osteocalcin gene transcription as well as transcription of other genes associated with osteoblast differentiation--a phenomenon the authors describe as phenotype suppression. Expand
Catalytically critical nucleotide in domain 5 of a group II intron.
Domain 5 (D5) is a small hairpin structure within group II introns. A bimolecular assay system depends on binding by D5 to an intron substrate for self-splicing activity. In this study, mutations inExpand
Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain
TLDR
Structural and biochemical studies and structure-based amino acid sequence analysis reveal that the key polar residues forming the inter-MyTH4/FERM interface are absolutely conserved in all MyTH4–FERM tandem-containing proteins, suggesting that the supramodular nature of the MyTH3–FERM tandem is likely a general property for all Myth4-FERM proteins. Expand
Isolation of a 90-kD Microtubule-Associated Protein from Tobacco Membranes.
TLDR
Dark-field microscopy of in vitro-assembled microtubules showed that the eluted proteins from both fractions induce micro Tubulin bundling and, in the presence of purified tubulin, promote microtubule elongation. Expand
Determination of the side chain pKa values of the lysine residues in calmodulin.
  • M. Zhang, H. Vogel
  • Medicine, Chemistry
  • The Journal of biological chemistry
  • 25 October 1993
TLDR
The results indicate that pKa values, rather than structural and steric effects, play the dominant role in determining the reactivity of Lys side chains towards small electrophilic chemical modification reagents. Expand
Regulation and differential expression of neutral endopeptidase 24.11 in human endothelial cells.
TLDR
Endothelial neutral endopeptidase is constitutively expressed in endothelial cells from different origins and is inducible by thrombin via activation of the protein kinase C pathway. Expand
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