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Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.
The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
A screening for BRCA1 mutations in breast and breast-ovarian cancer families from the Stockholm region.
To identify BRCA1 germ-line mutations in the breast and breast-ovarian cancer families in the Stockholm region, DNA from 174 patients from these families were studied using various mutation screening techniques, followed by direct DNA sequencing.
TGFBR1 variants TGFBR1*6A and Int7G24A are not associated with an increased familial colorectal cancer risk
- J. Skoglund Lundin, J. Vandrovcova, A. Lindblom
- Medicine, BiologyBritish Journal of Cancer
- 28 April 2009
This study provides no substantial support for the hypothesis that the polymorphic variants TGFBR1*6A or Int7G24A contribute to familial CRC risk and cannot, however, exclude the possibility that TGF BR1 variants have a modifying effect on inherited risk per se.
Screening of 229 family cancer patients for a germline estrogen receptor gene (ESR) base mutation
Screening for TP53 mutations in patients and tumours from 109 Swedish breast cancer families.
- M. Zelada-Hedman, A. L. BÃ¸rresen-Dale, A. Claro, J. Chen, L. Skoog, A. Lindblom
- Biology, MedicineBritish Journal of Cancer
To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic…
Estrogen receptor beta in breast cancer.
The possibility that ERbeta-selective ligands may well represent a useful class of pharmacological tools with a novel target, namely proliferating cells expressing ERbeta, is examined.
Genetic rearrangements in sporadic and familial gastric carcinomas detected with microsatellite markers.
- M. Zelada-Hedman, L. Iselius, A. Lindblom
- Medicine, BiologyEuropean journal of surgical oncology : the…
- 1 December 1994
The results suggest that different types of genes are involved in initiation and progression of gastric cancer in sporadic and familial Gastric cancer.
High expression of the EGFR in fibroadenomas compared to breast carcinomas.
It is suggested that the epidermal growth factor receptor plays an important role in the development of fibroadenomas and could be of importance in breast carcinogenesis.
TGFBR 1 variants TGFBR 1 * 6 A and Int 7 G 24 A are not associated with an increased familial colorectal cancer risk
Loss of heterozygosity studies in tumors from families with breast-ovarian cancer syndrome
- M. Zelada-Hedman, M. Torroella, R. Mesquita, M. Nordenskjöld, L. Skoog, A. Lindblom
- Biology, MedicineHuman Genetics
- 1 September 1994
The results do not support the idea that BRCA1 is a tumor suppressor gene, and it is suggested that the disease segregating in these families is linked to one or more different loci.