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Design of multistable RNA molecules.
TLDR
It is argued that both the general properties of the sequence structure map of RNA secondary structures and the ease with which the design tool finds bistable RNAs strongly indicates that RNA switches are easily accessible in evolution.
Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane
TLDR
It is proposed that the inhibition of D-serine synthesis caused by translocation of SR to the membrane provides a fail-safe mechanism to prevent NMDAR overactivation in vicinal cells or synapses.
Design of Multi-Stable RNA Molecules
TLDR
It is argued that both the general properties of the sequence-structure map of RNA secondary structures and the ease with which the design tool finds bi-stable RNAs strongly indicates that RNA switches are easily accessible in evolution.
Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS.
The rhizomes of Peucedanum ostruthium (L.) Koch (masterwort) are traditionally used in the alpine region as ingredient of liqueurs and bitters, and as a herbal drug. A sensitive and specific
Equisetum arvense (common horsetail) modulates the function of inflammatory immunocompetent cells
TLDR
The data indicate that the used extract of Equisetum arvense interferes with the polyfunctionality of immunocompetent cells thereby providing an anti-inflammatory mode-of-action.
Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry.
TLDR
It is demonstrated that ETD can be implemented in a mass spectrometric method to monitor the conformational dynamics of proteins in solution at single-residue resolution.
Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with single residue resolution.
TLDR
It is shown that electron transfer dissociation in a 3D-quadrupole ion trap retains the site-specific solution-phase deuterium incorporation pattern and allows for localization of incorporated deuteria with single residue resolution, and this finding is exploited to monitor how collisional activation induces proton mobility in a gaseous peptide ion at various levels of vibrational excitation.
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