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Crystal Structure of the Ribosome at 5.5 Å Resolution
We describe the crystal structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution. All of the 16S, 23S, and 5SExpand
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X-ray crystal structures of 70S ribosome functional complexes.
Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of theExpand
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Crystal Structure of the Eukaryotic Ribosome
Macromolecular Message Translation The ribosome is a macromolecular machine that translates the sequence of messenger RNA into proteins in all living cells. Structures of prokaryotic ribosomes haveExpand
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Structural aspects of messenger RNA reading frame maintenance by the ribosome
One key question in protein biosynthesis is how the ribosome couples mRNA and tRNA movements to prevent disruption of weak codon-anticodon interactions and loss of the translational reading frameExpand
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The Path of Messenger RNA through the Ribosome
Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove thatExpand
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Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes
The position of mRNA on 40S ribosomal subunits in eukaryotic initiation complexes was determined by UV crosslinking using mRNAs containing uniquely positioned 4‐thiouridines. Crosslinking of mRNAExpand
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Structured mRNAs Regulate Translation Initiation by Binding to the Platform of the Ribosome
Gene expression can be regulated at the level of initiation of protein biosynthesis via structural elements present at the 5' untranslated region of mRNAs. These folded mRNA segments may bind to theExpand
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High-resolution structure of the eukaryotic 80S ribosome.
The high-resolution structure of the eukaryotic ribosome from yeast, determined at 3.0-Å resolution, permitted the unambiguous determination of the protein side chains, eukaryote-specific proteins,Expand
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A new system for naming ribosomal proteins.
A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it. The objective is to eliminate the confusion caused by the assignment ofExpand
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