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The female, red Duroc pig as an animal model of hypertrophic scarring and the potential role of the cones of skin.
Hypertrophic scarring occurs after deep dermal wounds. Our understanding of the etiology is poor; one reason is the lack of an animal model. In 1972, Silverstein described scarring in the Duroc pigExpand
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Cones of skin occur where hypertrophic scar occurs
Hypertrophic scarring is devastating for the patient, however the pathophysiology and treatment remain unknown after decades of research. The process follows deep dermal injury, occurs only onExpand
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Recombinant human macrophage colony‐stimulating factor‐induced thrombocytopenia in dogs
Summary. To characterize recombinant human macrophage‐colony stimulating factor (rhM‐CSF)‐associated thrombocytopenia (TCP), in vivo studies were performed in dogs, including the biodistributions andExpand
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Tolerance to vascularized kidney grafts in canine mixed hematopoietic chimeras1
Background. Recent progress in allogeneic hematopoietic stem cell transplantation provides new methods for reliable engraftment with nonlethal conditioning regimens. These techniques have beenExpand
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FLT3 ligand promotes engraftment of allogeneic hematopoietic stem cells without significant graft-versus-host disease1
Background. Graft-versus-host (GVH) reactions contribute to stable engraftment of allogeneic hematopoietic stem cell transplants. It was hypothesized that the in vivo expansion of recipient dendriticExpand
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Long-term tolerance to kidney allografts in a preclinical canine model.
Durable immune tolerance supporting vascularized allotransplantation offers the possibility of extending graft survival and avoiding harmful complications of chronic immunosuppression. ImmuneExpand
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Minor histocompatibility antigen-specific cytotoxic T lymphocytes generated with dendritic cells from DLA-identical littermates.
Donor cytotoxic T lymphocytes (CTL) specific for minor histocompatibility antigens (mHA) mediate the graft-versus-host effect whereas host mHA-specific CTL mediate graft rejection in the setting ofExpand
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What Role Is There for Antithymocyte Globulin in Allogeneic Nonmyeloablative Canine Hematopoietic Cell Transplantation?
Abstract We investigated whether pretransplantation immunosuppression with canine-specific rabbit antithymocyte globulin (ATG), combined with a suboptimal dose of 1 Gy of total body irradiationExpand
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Survival of small bowel transplants in canine mixed hematopoietic chimeras: preliminary results.
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Optimizing a canine survival model of orthotopic lung transplantation.
INTRODUCTION While acute models of orthotopic lung transplantation have been described in dogs, the technical considerations of developing a survival model in this species have not been elaborated.Expand
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