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Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
Fibrillar amyloid-beta (Aβ) is found in the brains of many cognitively normal older people. Whether or not this reflects a predisposition to Alzheimer's disease (AD) is unknown. We used PittsburghExpand
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Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer’s disease
Objective: Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer’s disease. Methods: A specificExpand
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Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model
Neurophysiological studies of the brain in normal and Parkinson's disease (PD) patients have indicated intricate connections for basal ganglia-induced control of signaling into the motor cortex. Expand
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Regional Effects of Donepezil and Rivastigmine on Cortical Acetylcholinesterase Activity in Alzheimer’s Disease
Donepezil and rivastigmine are acetylcholinesterase (AChE) inhibitors used to improve cholinergic neurotransmission and cognitive function in Alzheimer’s disease (AD). This study examined directExpand
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Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging
Abstract. The iodine-123 labelled selective ligand N-(3-iodoprop-2E-enyl)-2-β-carbomethoxy-3β-(4-methylphenyl)nortropane ([123I]PE2I) was evaluated as a probe for in vivo dopamine transporter imagingExpand
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Recent developments of the PET imaging agents for metabotropic glutamate receptor subtype 5.
  • M. Yu
  • Medicine, Biology
  • Current topics in medicinal chemistry
  • 31 August 2007
Glutamate is a major excitatory neurotransmitter in central nervous system (CNS) acting through ionotropic and G-protein coupled metabotropic glutamate receptors. Metabotropic glutamate receptor 5Expand
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Preparation of [18F]β-CFT-FP and [11C]β-CFT-FP, selective radioligands for visualisation of the dopamine transporter using positron emission tomography (PET)
In this study the N-fluoropropyl analogue of the cocaine congener β-CFT (I), N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-fluorophenyl)nortropane (β-CFT-FP, III), was labelled with 18F or 11C. SynthesesExpand
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Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain
Introduction11C-ER176 is a new PET tracer to quantify the translocator protein (TSPO), a biomarker for inflammation. The aim of this study was to perform a head-to-head comparison between 11C-ER176Expand
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Assembly of foam and honeycomb films of a diblock copolymer doped with Au or Ag nanoparticles at the liquid/liquid interface and their catalytic properties
Composite thin films of poly(t-butyl methacrylate)-block-poly(2-vinyl pyridine) (PtBMA-b-P2VP) doped with silver or gold nanoclusters or nanoparticles were fabricated at the liquid/liquid interfaceExpand
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Metabolism of [123I]epidepride may affect brain dopamine D2 receptor imaging with single-photon emission tomography
Abstract.Iodine-123 labelled epidepride is a novel radiopharmaceutical for the study of cerebral dopamine D2 receptors using single-photon emission tomography (SPET). A lipophilic labelled metaboliteExpand
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