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The evolution of Metriorhynchoidea (mesoeucrocodylia, thalattosuchia): an integrated approach using geometric morphometrics, analysis of disparity, and biomechanics
This study illustrates the importance of using a varied toolkit of techniques that together with phylogeny, quantitative assessment of diversity, form, and function help elucidate the macroevolutionary pattern of fossil clades.
Reanalysis of P2X7 Receptor Expression in Rodent Brain
It is found that P2X7 receptor protein is strongly and reliably detected in the submandibular gland and lung of wild-type mice but not in either of the P2x7-/- mice, and it is failed to find evidence for P2 X7 protein in hippocampal neurons or their input-output projections.
An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
A weakly related gene in the genome of the social amoeba Dictyostelium discoideum is identified and it is shown that it encodes a membrane ion channel activated by ATP, demonstrating a new functional role for P2X receptors on intracellular organelles, in this case in osmoregulation.
Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells.
Red-cell and Xenopus oocyte expression studies showed that the DeltaV850 and A858D mutant proteins have greatly decreased anion transport activity when present as compound heterozygotes, suggesting dRTA might arise by a different mechanism for each mutation.
Altered Hippocampal Synaptic Potentiation in P2X4 Knock-Out Mice
It is suggested that calcium entry through subsynaptic P2X4 receptors during high-frequency stimulation contributes to synaptic strengthening.
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
NRTIs improved outcomes in several NLRP3 inflammasome-dependent mouse models of inflammation, including age-related macular degeneration and graft-versus-host disease, and suggest that NRTIs are ripe for drug repurposing in P2X7-driven diseases.
Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP
Single amino acid differences between species can account for large changes in agonist effectiveness and differentiate between the two widely used agonists at P2X7 receptors.
What is Geosaurus? Redescription of Geosaurus giganteus (Thalattosuchia: Metriorhynchidae) from the Upper Jurassic of Bayern, Germany
The holotype and referred specimens of Geosaurus giganteus, a metriorhynchid crocodile from the Tithonian (Upper Jurassic) of Germany, is redescribed, along with a historical overview of the genus
The oldest known metriorhynchid super-predator: a new genus and species from the Middle Jurassic of England, with implications for serration and mandibular evolution in predacious clades
It is shown that this specimen, and several isolated teeth, represents the oldest known remains of a large-bodied predatory metriorhynchid, and a new phylogenetic analysis finds Tyrannoneustes to be the sister taxon to the subclade Geosaurini.
Pseudoapoptosis Induced by Brief Activation of ATP-gated P2X7 Receptors*
The ROCK-1 pathway appears largely responsible for cell death, which occurs after prolonged stimulation of P2X7 receptors, and it is suggested that the former mechanism underlies the reversible pseudoapoptotic events induced by brief activation of P1x7 receptors.